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Poster

March 28, 2024

CAR-T cells morphological characteristics and dynamics in peripheral blood, evaluated by a novel microscopy platform

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Objective:

The dynamics of CAR-T quantity and subtypes in PBS were evaluated using the FFM platform and correlated with responsiveness to treatment and treatment-related toxicities.

  • Development of Interactive Hematology Atlas/Teaching Database for Resident Education and Resident Attitudes and Feedback Toward Full Field Microscopy

Conclusion:

In this study we show that CAR-T cells has heterogeneous morphology identified in PBS. Specific morphological features in specific days were associated with outcome and therapy related measurements. Thus, morphological CAR-T surveillance using FFM might serve as an available,toxicities, emphasizing that CAR-T monitoring require quantitative, qualitative and repeated simple and inexpensive method to provide clinically relevant insights.

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